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Hemic and Lymphatic: vaso-occlusive disaster: In a little, prematurely terminated review of REVATIO (sildenafil) in individuals with pulmonary arterial hypertension (PAH) secondary to sickle mobile disorder, vaso-occlusive crises demanding hospitalization ended up far more usually reported in sufferers who received sildenafil than in People randomized to placebo. The medical relevance of this obtaining to men treated with VIAGRA for ED is not really known.
Hearing: Scenarios of unexpected reduce or lack of hearing are documented postmarketing in temporal association with the usage of PDE5 inhibitors, which include VIAGRA. In a number of the cases, medical situations as well as other aspects ended up described which will have also played a job in the otologic adverse occasions.
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At 24 hours the plasma amounts of sildenafil were being nonetheless roughly 200 ng/mL, compared to about five ng/mL when sildenafil was dosed on your own. This really is in keeping with ritonavir's marked effects on the wide selection of P450 substrates. VIAGRA had no effect on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
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